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pentobarbital will minimize the extent or impact of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will decrease the level or result of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with powerful CYP3A4 inducers is not real